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Choose the source of your image (Take a Photo or Choose from the gallery).
Allow the app to access the photos on your device.
You can now choose the photo you want and it will be set as the profile picture for your Signal Messaging App. Now, one thing you would like to know here, is that Signal will have no access to the media you select or share on the platform, thanks to the end to end encryption, so rest assured, your photos are safe.
However, if you are a bit paranoid, and you are using an iPhone, you can select how many photos you want to allow the app to access, thereby maintaining another layer of privacy to the process.