At the 72nd ASMS Conference on Mass Spectrometry and Allied Topics, Waters Corporation has unveiled the Xevo™ MRT, a groundbreaking benchtop mass spectrometer that sets new benchmarks for delivering high resolution and speed – critical capabilities for large-scale population and epidemiology studies. Building upon the innovative technology pioneered by the Waters SELECT SERIES™ MRT MS, the new Xevo MRT combines the raw power and resolution speed of multi-reflecting time-of-flight (MRT) and hybrid quadrupole time-of-flight (QTof) technologies within a flexible benchtop platform.
Accelerating Discovery with High-Quality Data at Unprecedented Speeds
“Understanding complex diseases requires analysis of thousands of samples from large human cohorts to provide statistically valid studies. This puts increased pressure on drug discovery scientists to deliver high-quality data in shorter run times,” said Dr. Udit Batra, CEO and President of Waters Corporation. “The Xevo MRT mass spectrometer is a next generation QTof built from the ground up to address this unmet need, delivering high resolution and speed without compromising analytical performance.”
The Xevo MRT system delivers a class-leading 100,000 full width half maximum (FWHM) resolution at an astonishing 100 Hz MS/MS scan speed, coupled with sub-500 parts per billion (ppb) mass accuracy. This groundbreaking combination enables deeper probing of biologically relevant concentrations with unparalleled levels of mass accuracy, independent of acquisition rate.
Waters Xevo MRT multi-reflecting hybrid QTof mass spectrometer delivers 100K FWHM resolution at 100 Hz with sub-ppm mass accuracy for confident identification and greater laboratory productivity.
Accelerating Target Validation and Phenotyping Studies
“The Xevo MRT MS is impressive technology capable of higher sample throughput combined with extremely high precision, which can significantly advance target validation and phenotyping studies,” said Professor Perdita Barran, Chair of Mass Spectrometry at the University of Manchester. “The increase in scan speed and data quality are critical as it can allow us to run more samples in less time without compromising confidence in our data, and we are very excited by how this is allowing us to accelerate the development of a diagnostic test for Parkinson’s Disease.”
Innovative Multi-Reflecting Time-of-Flight Design
The innovative multi-reflecting time-of-flight design of the Xevo MRT MS offers scientists the power to work at maximum resolution with high sensitivity and fast data acquisition rates. This groundbreaking architecture ensures confident identification of analytes across a range of samples and complex matrices, generating comprehensive and highly accurate mass data for scientific interpretation.
Complete Workflows for Metabolomics, Lipidomics, and Metabolite Identification
Waters offers complete workflows for metabolomic, lipidomic, and metabolite identification studies with the Xevo MRT MS. These integrated solutions include Waters’ high-throughput ACQUITY™ UPLC™ Systems, UPLC Column chemistries, and waters_connect™ Software for data acquisition, processing, and reporting. The system also supports universal data-sharing via mzML file formats with third-party informatics software, including popular applications from Mass Analytica™ such as MARS, Lipostar2, and MassMetaSite.
The Waters Xevo MRT MS is available for ordering today, with shipments scheduled for the second half of 2024, poised to revolutionize benchtop mass spectrometry and accelerate scientific breakthroughs across a wide range of applications.
